Key result
Angiotensin-(1-7) significantly stimulated the proliferation of human hematopoietic progenitor cells, increasing human HLA-I+ and CD34+ cells in the bone marrow of NOD/SCID mice by 42-fold and 600-fold.
Why the study?
Does Angiotensin-(1-7) stimulate proliferation and differentiation of hematopoietic progenitor cells in vitro and in vivo?
Population
Human cord blood-derived CD34+ and mononuclear cells and NOD/SCID mice engrafted with human cord blood…
Comparison
Angiotensin- vs PBS (vehicle) control
Design
Preclinical
Follow-up
30 days (in vivo)
Authors
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Hypothesis-generating for hematopoietic regeneration; leaves open clinical translation pending human studies.
Does Angiotensin-(1-7) stimulate proliferation and differentiation of hematopoietic progenitor cells in vitro and in vivo?
Effect estimate: 42-fold increase
Absolute Event Rate: 21.2% vs 0.5%
p-value: p=≤0.001
Angiotensin-(1-7) significantly stimulates the proliferation and engraftment of human hematopoietic progenitor cells in vivo, suggesting potential therapeutic utility in regenerative medicine.
Heringer‐Walther et al. (2009) studied Hematopoietic progenitor cell stimulation. Angiotensin-(1-7) vs. PBS was evaluated on Percentage of human HLA-I+ cells in bone marrow of NOD/SCID mice (42-fold increase, p=≤0.001). Angiotensin-(1-7) significantly stimulated the proliferation of human hematopoietic progenitor cells, increasing human HLA-I+ and CD34+ cells in the bone marrow of NOD/SCID mice by 42-fold and 600-fold.
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