Key result
Levosimendan successfully improved left heart function and decreased lactate and brain natriuretic peptide levels in a neonate with severe coarctation of aorta and low cardiac output syndrome.
Why the study?
Does levosimendan improve cardiac function and biomarkers in a critically ill neonate with severe coarctation of aorta and low cardiac output syndrome?
Case Report (n=1)
Does levosimendan improve cardiac function and biomarkers in a critically ill neonate with severe coarctation of aorta and low cardiac output syndrome?
Levosimendan may be safely and successfully used to manage low cardiac output syndrome in neonates with severe coarctation of the aorta awaiting surgical repair.
Suggests possible levosimendan role in neonates with coarctation and low output; hypothesis-generating, needs controlled trials.
We report successful use of levosimendan after failed balloon angioplasty in a critically ill neonate with coarctation of aorta (CoA) and severe low cardiac output syndrome (LCOS). Treatment with levosimendan improved left heart function, and decreased lactate and brain natriuretic peptide levels. To our knowledge, this is the first report on the safe and successful use of levosimendan in the management of LCOS due to severe CoA in a neonate awaiting surgical repair.
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Boegli et al. (2013) conducted a case report in Severe coarctation of aorta and low cardiac output syndrome (n=1). Levosimendan was evaluated on Left heart function, lactate, and brain natriuretic peptide levels. Levosimendan successfully improved left heart function and decreased lactate and brain natriuretic peptide levels in a neonate with severe coarctation of aorta and low cardiac output syndrome.
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