Key result
BW-A1433U reduced the incidence of second- or third-degree atrioventricular block at 15 seconds postdefibrillation from 47% to 6% in anesthetized pigs.
Why the study?
Does BW-A1433U prevent postdefibrillation bradyarrhythmia and hemodynamic depression in a pig model of ventricular fibrillation?
Population
Halothane-nitrous oxide-anesthetized pigs subjected to repetitive episodes of ventricular fibrillation and…
Comparison
BW-A1433U 5 mg/kg i.v. vs Control in protocol 1; methoxamine alone and…
Design
Preclinical
Follow-up
15 to 30 seconds postdefibrillation
Authors
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Adenosine antagonism may mitigate postdefibrillation bradyarrhythmia; hypothesis-generating in pig VF models and leaves open human translation.
Does BW-A1433U prevent postdefibrillation bradyarrhythmia and hemodynamic depression in a pig model of ventricular fibrillation?
Absolute Event Rate: 6% vs 47%
The adenosine antagonist BW-A1433U reverses and prevents postdefibrillation bradyarrhythmia and hemodynamic depression in a pig model, suggesting endogenous adenosine mediates postdefibrillation cardiovascular collapse.
Wesley et al. (1989) studied Postdefibrillation bradyarrhythmia and hemodynamic depression. BW-A1433U vs. Control was evaluated on Second- or third-degree atrioventricular block at 15 seconds postdefibrillation. BW-A1433U reduced the incidence of second- or third-degree atrioventricular block at 15 seconds postdefibrillation from 47% to 6% in anesthetized pigs.
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