February 1, 1995Circulation

Metabolic Determinants of Defibrillation

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Why the study?

Does adenosine infusion increase defibrillation threshold in dogs?

Population

Dogs (n=21 for transthoracic DFT, n=10 for transmyocardial DFT)

Comparison

Infusion of adenosine and dipyridamole… vs Baseline or innervated state

Design

Preclinical

Authors

BLBruce B. LermanElectrophysiology EEErica D. EngelsteinRush University Medical Center

Discussion

Member takes

Implication

Adenosine may raise defibrillation thresholds in VF; hypothesis-generating for A1 antagonists facilitating defibrillation.

Structured PICO

Does adenosine infusion increase defibrillation threshold in dogs?

Population

Dogs (n=21 for transthoracic DFT, n=10 for transmyocardial DFT)

Intervention

Infusion of adenosine (300 micrograms.kg-1.min-1) and dipyridamole (0.25 mg/kg); pretreatment with A1 adenosine receptor antagonist 8-cyclopentyltheophylline (CPT) 5 mg/kg; denervated state (propranolol 0.2 mg/kg plus bilateral vagotomy)

Comparator

Baseline or innervated state

Outcome

Defibrillation threshold (DFT)surrogate

Adenosine significantly increases defibrillation threshold through an A1 receptor-mediated antiadrenergic mechanism, suggesting that A1 antagonists could facilitate defibrillation during prolonged ventricular fibrillation.

Cite This Study

Lerman et al. (1995) studied this question.

synapsesocial.com/papers/6a71d41b35aa2c282ce2f345 https://doi.org/10.1161/01.cir.91.3.838

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Metabolic Determinants of Defibrillation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Metabolic Determinants of Defibrillation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider