Key result
In anesthetized pigs, alpha- and beta-adrenoceptor agonists and antagonists did not significantly alter the defibrillation threshold using a sequential-pulse technique.
Why the study?
Do alpha- and beta-adrenoceptor agonists and antagonists alter the internal cardiac defibrillation threshold in anesthetized pigs?
Population
Anesthetized pigs (n=8 for most experiments, n=7 for single-pulse isoproterenol)
Comparison
Alpha- and beta-adrenoceptor agonists and… vs Control (before drug administration)
Design
Preclinical
Authors
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Adrenergic agents leave sequential-pulse defibrillation threshold unchanged in pigs; leaves open technique-specific effects and clinical translation.
Do alpha- and beta-adrenoceptor agonists and antagonists alter the internal cardiac defibrillation threshold in anesthetized pigs?
p-value: p=NS
Adrenergic modulation with isoproterenol decreases the defibrillation threshold when using a single-pulse method, suggesting beta-adrenergic tone may affect implantable defibrillator efficacy.
Rattes et al. (1987) studied Defibrillation threshold (n=8). Alpha- and beta-adrenoceptor agonists and antagonists vs. Control was evaluated on Defibrillation threshold using a sequential-pulse technique (p=NS). In anesthetized pigs, alpha- and beta-adrenoceptor agonists and antagonists did not significantly alter the defibrillation threshold using a sequential-pulse technique.
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