Key result
Norepinephrine infusion reduced the defibrillation threshold by 22.6% from baseline (P=0.008) in patients with implanted cardioverter defibrillators, while epinephrine and placebo had no effect.
Why the study?
Does epinephrine or norepinephrine infusion reduce defibrillation threshold in patients with implanted cardioverter defibrillators?
Population
50 patients with implanted cardioverter defibrillators
Comparison
7-minute infusion of epinephrine or norepinephrine vs 7-minute infusion of placebo
Design
RCT, stratified by beta-blocker use and then randomized, double-blind
Authors
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Norepinephrine may facilitate lower-energy defibrillation in ICD patients; extends evidence distinguishing catecholamine effects on defibrillation threshold.
RCT (n=50)
Double-blind
Stratified by beta-blocker use
Does epinephrine or norepinephrine infusion reduce defibrillation threshold in patients with implanted cardioverter defibrillators?
p-value: p=0.008
Norepinephrine infusion significantly reduces defibrillation threshold in patients with ICDs, whereas epinephrine's effect is dependent on concurrent beta-blocker use.
Kalus et al. (2005) conducted an RCT in Implanted cardioverter defibrillators (n=50). Epinephrine or norepinephrine vs. Placebo was evaluated on Defibrillation threshold (DFT) (p=0.008). Norepinephrine infusion reduced the defibrillation threshold by 22.6% from baseline (P=0.008) in patients with implanted cardioverter defibrillators, while epinephrine and placebo had no effect.