Key result
Pre-stroke use of beta-blockers was not associated with 3-month mortality (OR 0.86; 95% CI 0.49-1.52) or poor functional outcome in hypertensive patients with acute stroke.
Why the study?
Does pre-stroke use of beta-blockers improve functional outcome and mortality at 3 months in hypertensive patients with acute stroke?
Cohort (n=1,126)
Yes
Does pre-stroke use of beta-blockers improve functional outcome and mortality at 3 months in hypertensive patients with acute stroke?
Odds Ratio: 0.86 (95% CI 0.49–1.52)
Pre-stroke use of beta-blockers in hypertensive patients is not associated with worse functional outcomes or increased mortality at 3 months following an acute stroke.
No support for altering pre-stroke beta-blocker use in hypertensive stroke patients; leaves open confirmation via randomized trials.
The impact of beta-blockers (BB) treatment on stroke outcome is unclear. We used data from a prospective national stroke registry to assess the associations between use of BB and poor outcome 3 months after stroke. Using the National Acute Stroke Israeli (NASIS) registry, we identified 1126 patients with ischemic stroke and intracerebral hemorrhage with pre-stroke hypertension treatment, who were followed for 3-months. Functional outcome and mortality at 3-month were compared by use of BB, adjusting for demographics and clinical factors. Pre-stroke use of BB was reported by 615 (54.6%) patients. Users of BB showed higher rates of atrial fibrillation, heart disease, statin use, cancer, and severe stroke. Adjusted odds-ratios (ORs, 95% CI) for BB users compared with non-users 3 months after stroke were 0.86 (0.49-1.52) for mortality and 1.07 (0.76-1.50) for Barthel Index ≤60. In conclusion, treatment with BB is not associated with 3-month poor outcome in hypertensive patients.
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Eizenberg et al. (2018) conducted a cohort in ischemic stroke and intracerebral hemorrhage (n=1,126). Beta-blockers vs. non-users was evaluated on mortality at 3 months (OR 0.86, 95% CI 0.49-1.52). Pre-stroke use of beta-blockers was not associated with 3-month mortality (OR 0.86; 95% CI 0.49-1.52) or poor functional outcome in hypertensive patients with acute stroke.
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