Key result
Fibrin-associated large B-cell lymphoma can arise around vascular prostheses secondary to chronic Epstein-Barr virus infection and chronic inflammation.
Case Report
Fibrin-associated large B-cell lymphoma can arise around vascular prostheses and mimic a recurrent abdominal aortic aneurysm.
Consider rare periprosthetic lymphoma in recurrent AAA differentials; extends sparse case reports on vascular graft-associated malignancies.
Fibrin-associated large B-cell lymphoma (FA-LBCL) is a rare subtype of extranodal B-cell lymphoma that arises within the fibrinous material in cysts and pseudocysts, hematomas, cardiac myxomas, and prosthetic devices and is thought to occur secondary to chronic Epstein–Barr virus (EBV) infection in the setting of a chronic inflammatory state. EBV-infected B cells expressing latent membrane protein-1 are attacked by cytotoxic B cells under normal conditions, but under immunosuppressive conditions resulting from chronic inflammation caused by foreign materials, latent membrane protein-1 causes expression of Bcl-2, inhibiting EBV-infected cell apoptosis and providing favorable environments for the development of lymphoma.
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Sakai et al. (2023) conducted a case report in Fibrin-associated large B-cell lymphoma. Fibrin-associated large B-cell lymphoma can arise around vascular prostheses secondary to chronic Epstein-Barr virus infection and chronic inflammation.
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