Key result
A rare case of fibrin-associated Epstein-Barr virus-positive diffuse large B-cell lymphoma was incidentally discovered within a multinodular goiter, expanding the known locations for this disorder.
Why the study?
The pathogenesis and clinicopathologic features of fibrin-associated diffuse large B-cell lymphoma are poorly understood due to a limited number of cases.
Case Report (n=1)
This case report expands the known locations for fibrin-associated DLBCL to include multinodular goiter.
Expands recognized sites of fibrin-associated DLBCL; leaves open its prevalence and clinical relevance.
Fibrin-associated diffuse large B-cell lymphoma (fibrin-associated DLBCL) is a very rare subtype of Epstein-Barr virus (EBV)-associated DLBCL that usually develops within fibrin-rich lesions such as cardiac myxoma, chronic hematoma, thrombus, pseudocysts or cysts, prosthetic devices or breast implants. The pathogenesis as well as the clinicopathologic features of this usually indolent lymphoproliferative disorder, which are based on the analysis of a relatively limited number of cases, are still poorly known. Herein, we report a case of fibrin-associated DLBCL that was incidentally found within a multinodular goiter, a location not yet reported to our knowledge. Our findings not only illustrate further the specific nature of this peculiar lymphoproliferative disorder but also allow some interesting comments on its pathogenesis.
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Dargent et al. (2022) conducted a case report in Fibrin-associated diffuse large B-cell lymphoma (n=1). A rare case of fibrin-associated Epstein-Barr virus-positive diffuse large B-cell lymphoma was incidentally discovered within a multinodular goiter, expanding the known locations for this disorder.
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