Key result
Prazosin reduced lying blood pressure by 17/8 mm Hg and standing blood pressure by 24/14 mm Hg compared to placebo, though postural hypotension occurred in one third of patients.
Why the study?
Does prazosin reduce blood pressure in patients with hypertension?
RCT (n=12)
Double-blind
randomly allocated
Does prazosin reduce blood pressure in patients with hypertension?
Effect estimate: 17/8 mm Hg lower lying and 24/14 mm Hg lower standing
Prazosin effectively lowers lying and standing blood pressure in hypertensive patients but is associated with first-dose postural hypotension.
Prazosin effectively lowers BP in hypertension but requires postural hypotension caution; confirms its role as an antihypertensive in RCTs.
A double-blind placebo crossover trail (2 periods, each of 6 wk) was carried out in 12 patients. In the first period the patients were randomly allocated to either their individual established dose of prazosin or to the same number of placebo tablets; treatment was reversed after 6 wk. Blood pressure was higher by 17/8 mm Hgin the lying posture and by 24/14 mm Hg in the standing posture during placebo than during prazosin treatment. Standing pulse rate and body weight were higher and plasma renin activity lower during prazosin treatment. Postural hypotension occurring 1 to 2 hr after the first few doses was noted in one third of the patients when they resumed prazosin treatment after the placebo course.
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Bolli et al. (1976) conducted an RCT in hypertension (n=12). prazosin vs. placebo was evaluated on Blood pressure (17/8 mm Hg lower lying and 24/14 mm Hg lower standing). Prazosin reduced lying blood pressure by 17/8 mm Hg and standing blood pressure by 24/14 mm Hg compared to placebo, though postural hypotension occurred in one third of patients.
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