Key result
The insertion/deletion polymorphism of the ACE gene did not significantly influence adherence to ACE inhibitors (DD vs II genotype: RR 1.17; 95% CI 0.78-1.77).
Why the study?
Does the insertion/deletion polymorphism of the ACE gene influence adherence to ACE inhibitors in subjects starting ACE inhibitor therapy?
Cohort (n=239)
Does the insertion/deletion polymorphism of the ACE gene influence adherence to ACE inhibitors in subjects starting ACE inhibitor therapy?
Relative Risk: 1.17 (95% CI 0.78–1.77)
The insertion/deletion polymorphism of the ACE gene does not appear to influence adherence to ACE inhibitor therapy.
No association with adherence in this cohort; leaves open whether other variants affect ACE inhibitor persistence.
AIMS: We investigated whether the insertion/deletion (I/D) polymorphism of the ACE gene modified the adherence to ACE inhibitors as measured by the discontinuation of an ACE inhibitor, or addition of another antihypertensive drug. METHODS: This was a cohort study among 239 subjects who started ACE inhibitor therapy. A Cox proportional hazard model was used to calculate relative risk (RR). RESULTS: During follow-up there was no significant difference between subjects with the DD, ID or II genotype (DD vs II; RR = 1.17, 95%CI: 0.78, 1.77 and ID vs II; RR = 1.06, 95%CI: 0.73, 1.55) in adherence. CONCLUSIONS: The I/D polymorphism of the ACE gene does not influence the adherence to ACE inhibitors.
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Schelleman et al. (2005) conducted a cohort in Patients starting ACE inhibitor therapy (n=239). Insertion/deletion (I/D) polymorphism of the ACE gene (DD genotype) vs. II genotype was evaluated on Adherence to ACE inhibitors (discontinuation of an ACE inhibitor, or addition of another antihypertensive drug) (RR 1.17, 95% CI 0.78-1.77). The insertion/deletion polymorphism of the ACE gene did not significantly influence adherence to ACE inhibitors (DD vs II genotype: RR 1.17; 95% CI 0.78-1.77).
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