Key result
A ventricular septal defect in children with complete transposition of the great vessels was associated with left ventricular pressures >70% of systemic in 92% of cases, compared to 5% in controls.
Why the study?
Does the presence of a ventricular septal defect or patent ductus arteriosus affect left ventricular pressure in infants and children with complete transposition of the great vessels?
Population
80 infants and children with complete transposition of the great vessels and known presence of a ventricular…
Comparison
Presence of a ventricular septal defect or… vs Closed ventricular septum and no ductus
Design
Cross-sectional
Authors
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May warrant closer pulmonary pressure monitoring in TGA with VSD; leaves open whether early repair alters disease progression.
Observational (n=80)
Does the presence of a ventricular septal defect or patent ductus arteriosus affect left ventricular pressure in infants and children with complete transposition of the great vessels?
Absolute Event Rate: 92% vs 5%
In infants with complete transposition of the great vessels, the presence of a ventricular septal defect is associated with significantly elevated left ventricular pressures, indicating a high risk for developing obstructive pulmonary vascular disease.
Shaher et al. (1968) conducted an observational in Complete transposition of the great vessels (n=80). Ventricular septal defect vs. Closed ventricular septum and no patent ductus arteriosus was evaluated on Left ventricular pressure greater than 70% of the systemic pressure. A ventricular septal defect in children with complete transposition of the great vessels was associated with left ventricular pressures >70% of systemic in 92% of cases, compared to 5% in controls.
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