What is the clinical evidence from this study?

Study design: Observational. Population: Chronic descending thoracic aortic dissection (n=19). Intervention: Multi-velocity encoding 4D-flow MRI vs. Healthy volunteers. Primary outcome: Blood flow velocity and flow rate (p=<0.05).

June 1, 2017AortaOpen Access

Multi-Velocity Encoding Four-Dimensional Flow Magnetic Resonance Imaging in the Assessment of Chronic Aortic Dissection

Q: What are the key findings of this study?

Multi-velocity encoding 4D-flow MRI revealed reduced blood flow velocity and flow rate in the true lumen of CDTAD patients compared with normal aortas of healthy participants (p < 0.05).

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Key result

Multi-velocity encoding 4D-flow MRI revealed reduced blood flow velocity and flow rate in the true lumen of CDTAD patients compared with normal aortas of healthy participants (p < 0.05).

Why the study?

Does multi-VENC 4D-flow MRI enable detailed assessment of blood flow patterns in patients with chronic descending thoracic aortic dissection compared to healthy volunteers?

Population

10 patients with chronic descending thoracic aortic dissection following surgical repair of ascending aortic…

Comparison

Four-dimensional-flow magnetic resonance imaging… vs Healthy volunteers undergoing the same imaging…

Design

Cross-sectional

Authors

ASAndrew G. SherrahRoyal North Shore Hospital FCFraser M. CallaghanUniversity Children's Hospital Zurich RPRajesh PuranikCardiac Imaging

Discussion

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Implication

Multi-VENC 4D-flow MRI detects reduced true lumen flow in CDTAD; hypothesis-generating for risk stratification, needs prospective validation.

Study Design

Type

Observational (n=19)

Structured PICO

Does multi-VENC 4D-flow MRI enable detailed assessment of blood flow patterns in patients with chronic descending thoracic aortic dissection compared to healthy volunteers?

Population

10 patients with chronic descending thoracic aortic dissection and 9 healthy volunteers evaluated with multi-velocity encoding 4D-flow MRI.

Exposure

Four-dimensional (4D)-flow magnetic resonance imaging (MRI) with a multi-velocity encoding (multi-VENC) technique at 3T.

Comparator

Healthy volunteers undergoing the same imaging protocol.

Outcome

Dynamic quantification of blood volume and velocity throughout the cardiac cycle in the ascending and descending thoracic aorta.surrogate

Main Result

p-value: p=<0.05

Multi-VENC 4D-flow MRI can quantify complex flow dynamics, such as reduced flow velocity and increased flow reversal in the false lumen, in patients with chronic aortic dissection.

Cite This Study

Sherrah et al. (2017) conducted an observational in Chronic descending thoracic aortic dissection (n=19). Multi-velocity encoding 4D-flow MRI vs. Healthy volunteers was evaluated on Blood flow velocity and flow rate (p=<0.05). Multi-velocity encoding 4D-flow MRI revealed reduced blood flow velocity and flow rate in the true lumen of CDTAD patients compared with normal aortas of healthy participants (p < 0.05).

synapsesocial.com/papers/6a9cbd05a2aa65bfe097a65e https://doi.org/10.12945/j.aorta.2017.16.046

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Implication

Multi-VENC 4D-flow MRI detects reduced true lumen flow in CDTAD; hypothesis-generating for risk stratification, needs prospective validation.

Multi-Velocity Encoding Four-Dimensional Flow Magnetic Resonance Imaging in the Assessment of Chronic Aortic Dissection

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Cite This Study

Multi-Velocity Encoding Four-Dimensional Flow Magnetic Resonance Imaging in the Assessment of Chronic Aortic Dissection

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Cite This Study

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Also Consider