What is the clinical evidence from this study?

Study design: Observational. Population: Aortic Dissection (n=16). Intervention: True lumen (4D flow MRI) vs. False lumen. Primary outcome: Mean area across all levels (mm2) (p=<0.0001).

What does this research mean for the field?

In patients with aortic dissection, 4D flow MRI demonstrates that the true lumen has a significantly smaller mean area and higher average through-plane velocity compared to the false lumen. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

June 8, 2018Scientific ReportsOpen Access

Quantitative Study of Abdominal Blood Flow Patterns in Patients with Aortic Dissection by 4-Dimensional Flow MRI

Q: What are the key findings of this study?

4D flow MRI revealed that the true lumen had a significantly smaller mean area (192.73 vs 432.46 mm2) and higher average through-plane velocity compared to the false lumen in aortic dissection.

Q: What does this research mean for the field?

In patients with aortic dissection, 4D flow MRI demonstrates that the true lumen has a significantly smaller mean area and higher average through-plane velocity compared to the false lumen. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

View Full Paper

Ask AI

Bookmark

Key result

4D flow MRI revealed that the true lumen had a significantly smaller mean area (192.73 vs 432.46 mm2) and higher average through-plane velocity compared to the false lumen in aortic dissection.

Why the study?

Can 4D flow MRI quantitatively assess hemodynamic differences between the true and false lumens in patients with aortic dissection?

Population

16 patients with sub-acute aortic dissection, mean age 51.19 years, without cardiac, hepatic, or renal…

Design

Cohort

Authors

DLDongting LiuQingdao University ZFZhanming FanCapital Medical University YLYu LiUniversity of Nebraska Medical Center

Discussion

Member takes

Overview

May support 4D flow MRI for lumen-specific hemodynamics in aortic dissection; hypothesis-generating, needs prospective validation.

Study Design

Type

Observational (n=16)

Multicenter

Structured PICO

Can 4D flow MRI quantitatively assess hemodynamic differences between the true and false lumens in patients with aortic dissection?

Population

16 patients (1 female, 15 males) with sub-acute aortic dissection (1 Stanford A, 15 Stanford B), mean age 51.19 years, without cardiac, hepatic, or renal function impairments.

Intervention

4D flow magnetic resonance imaging (MRI) and thoracic and abdominal computed tomography (CT) angiography

Outcome

Hemodynamic characteristics (velocity, flow, area, regurgitant fraction) of the true lumen (TL) and false lumen (FL) at four abdominal aortic levelssurrogate

Main Result

Absolute Event Rate: 192.73% vs 432.46%

p-value: p=<0.0001

4D flow MRI enables detailed quantitative assessment of complex hemodynamic alterations in the true and false lumens of patients with aortic dissection.

Limitations

Small number of participants and single-center experience
Low signal in the false lumen restricted analysis of flow features
Lack of a medically treated control group
Lack of longitudinal follow-up
Small sample size
Single-center experience
Low signal in the false lumen restricted flow feature analysis

Cite This Study

Liu et al. (2018) conducted an observational in Aortic Dissection (n=16). True lumen (4D flow MRI) vs. False lumen was evaluated on Mean area across all levels (mm2) (p=<0.0001). 4D flow MRI revealed that the true lumen had a significantly smaller mean area (192.73 vs 432.46 mm2) and higher average through-plane velocity compared to the false lumen in aortic dissection.

synapsesocial.com/papers/6a1562ff79ff98d0de4e8dd1 https://doi.org/10.1038/s41598-018-27249-9

View Full Paper

Ask AI

Bookmark

June 8, 2018Scientific ReportsOpen Access

Quantitative Study of Abdominal Blood Flow Patterns in Patients with Aortic Dissection by 4-Dimensional Flow MRI

View Full Paper

Ask AI

Bookmark

Key result

4D flow MRI revealed that the true lumen had a significantly smaller mean area (192.73 vs 432.46 mm2) and higher average through-plane velocity compared to the false lumen in aortic dissection.

Why the study?

Can 4D flow MRI quantitatively assess hemodynamic differences between the true and false lumens in patients with aortic dissection?

Population

16 patients with sub-acute aortic dissection, mean age 51.19 years, without cardiac, hepatic, or renal…

Design

Cohort

Authors

DLDongting LiuQingdao University ZFZhanming FanCapital Medical University YLYu LiUniversity of Nebraska Medical Center

Discussion

Member takes

Overview

May support 4D flow MRI for lumen-specific hemodynamics in aortic dissection; hypothesis-generating, needs prospective validation.

Study Design

Type

Observational (n=16)

Multicenter

Structured PICO

Can 4D flow MRI quantitatively assess hemodynamic differences between the true and false lumens in patients with aortic dissection?

Population

16 patients (1 female, 15 males) with sub-acute aortic dissection (1 Stanford A, 15 Stanford B), mean age 51.19 years, without cardiac, hepatic, or renal function impairments.

Intervention

4D flow magnetic resonance imaging (MRI) and thoracic and abdominal computed tomography (CT) angiography

Outcome

Hemodynamic characteristics (velocity, flow, area, regurgitant fraction) of the true lumen (TL) and false lumen (FL) at four abdominal aortic levelssurrogate

Main Result

Absolute Event Rate: 192.73% vs 432.46%

p-value: p=<0.0001

4D flow MRI enables detailed quantitative assessment of complex hemodynamic alterations in the true and false lumens of patients with aortic dissection.

Limitations

Small number of participants and single-center experience
Low signal in the false lumen restricted analysis of flow features
Lack of a medically treated control group
Lack of longitudinal follow-up
Small sample size
Single-center experience
Low signal in the false lumen restricted flow feature analysis

Cite This Study

synapsesocial.com/papers/6a1562ff79ff98d0de4e8dd1 https://doi.org/10.1038/s41598-018-27249-9

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark