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January 26, 2017PLoS ONEOpen Access

False Lumen Flow Patterns and their Relation with Morphological and Biomechanical Characteristics of Chronic Aortic Dissections. Computational Model Compared with Magnetic Resonance Imaging Measurements

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Population

33 consecutive patients with chronic dissection of the descending aorta during long-term follow-up…

Design

Cohort

Follow-up

3-12 months after the acute phase

Authors

PRPaula A. RudenickPSPatrick SegersVPVíctor Pineda

Discussion

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Overview

PC-MRI flow patterns may noninvasively indicate dissection morphology; leaves open prospective validation for expansion risk stratification.

Structured PICO

P
Population
33 consecutive patients with chronic dissection of the descending aorta (24 surgically-treated type A dissections and 9 medically-managed type B dissections) during long-term follow-up, evaluated 3-12 months after the acute phase.
I
Intervention
Phase-contrast magnetic resonance imaging (PC-MRI) to quantify instantaneous flow profiles in the false lumen at the diaphragm level, combined with a lumped-parameter computational model.
O
Outcome
False lumen flow patterns based on the direction of flow in systole and diastole, and their relation to morphological and biomechanical characteristics (wall stiffness, tear size/location, and presence of abdominal side branches).surrogate

False lumen flow patterns measured by PC-MRI can implicitly codify morphological information about key determinants of aortic expansion in chronic aortic dissections.

Cite This Study

Rudenick et al. (2017) studied this question.

synapsesocial.com/papers/6a82015c909f34cd697776edhttps://doi.org/10.1371/journal.pone.0170888
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Also Consider

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  1. 1Evaluation of Flow Volume and Flow Patterns in the Patent False Lumen of Chronic Aortic Dissections Using Velocity-Encoded Cine Magnetic Resonance Imaging2000 · 24 citations
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  3. 3Aortic Intimal Tears:Detection With Spiral Computed Tomography2003 · 51 citations
  4. 4Diagnosis and management of patients with aortic dissection2007 · 97 citations
  5. 5Modulation of coronary vasomotor tone in humans. Progressive endothelial dysfunction with different early stages of coronary atherosclerosis.1991 · 996 citations