Key result
Higher false lumen rotational flow, PWV, and thrombus percentage link to faster aortic growth.
Why the study?
False lumen patency in chronic aortic dissection is associated with dilation and adverse events, but predictors of adverse outcomes in this population remain limited.
Are false lumen flow dynamics and biomechanics assessed by 4D flow CMR associated with aortic growth rate in patients with chronic aortic dissection?
Comparison
False lumen flow dynamics and biomechanics assessed by 4D flow CMR and serial CTA
Design
Cohort study
Follow-up
Median 40 months
Authors
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Advanced CMR hemodynamics may help stratify risk in chronic aortic dissection; leaves open whether.
Cohort (n=54)
No
Are false lumen flow dynamics and biomechanics assessed by 4D flow CMR associated with aortic growth rate in patients with chronic aortic dissection?
Effect estimate: R = 0.393
p-value: p=0.006
In patients with chronic aortic dissection, 4D flow CMR-derived rotational flow, pulse wave velocity, and thrombus burden are associated with aortic growth rate and may help identify patients at higher risk of adverse events.
Guala et al. (2022) conducted a cohort in Chronic aortic dissection of the descending aorta (n=54). False lumen flow dynamics and biomechanics (in-plane rotational flow, pulse wave velocity, thrombus) was evaluated on Aortic growth rate (R = 0.393, p=0.006). In patients with chronic descending aortic dissection, false lumen in-plane rotational flow (p=0.006), pulse wave velocity (p=0.017), and thrombus percentage (p=0.037) were positively associated with aortic growth rate.
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