Key result
Administration of L-NNA during whole body heating significantly decreased left ear vascular conductance from 5.87 to 0.18 kHz/100 mmHg (P < 0.05), indicating NO mediates active vasodilation.
Why the study?
Does nitric oxide mediate active neurogenic vasodilation during whole body heating in the rabbit ear?
Does nitric oxide mediate active neurogenic vasodilation during whole body heating in the rabbit ear?
Absolute Event Rate: 0.18% vs 5.87%
p-value: p=< 0.05
Nitric oxide plays a key role in mediating active thermoregulatory vasodilation in the rabbit ear during whole body heating.
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Supports NO mediation of thermoregulatory vasodilation in rabbit ear; leaves open translation to human cutaneous circulation.
Taylor et al. (1993) studied hyperthermia. N omega-nitro-L-arginine (L-NNA) was evaluated on left ear vascular conductance (EVC) (p=< 0.05). Administration of L-NNA during whole body heating significantly decreased left ear vascular conductance from 5.87 to 0.18 kHz/100 mmHg (P < 0.05), indicating NO mediates active vasodilation.
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