January 1, 1993The Japanese Journal of PharmacologyOpen Access

Calcium-Induced Vasodilation Due to Increase in Nitric Oxide Formation in the Vascular Bed of Rabbit Ear Preparation

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Why the study?

Does calcium induce vasodilation via nitric oxide synthesis in the vascular bed of rabbit ear preparations?

Structured PICO

Does calcium induce vasodilation via nitric oxide synthesis in the vascular bed of rabbit ear preparations?

Population

Isolated rabbit ear preparation (vessel perfusion method)

Intervention

CaCl2 (6.25, 12.5 and 25 mg) injected in the perfused vessel, with or without norepinephrine (1.2 x 10(-7) M) pre-contraction, and in the presence of inhibitors (NG-nitro-L-arginine, methylene blue, indomethacin)

Comparator

Baseline/normal vascular tone vs norepinephrine-contracted tone; presence vs absence of inhibitors

Outcome

Vasodilation/vasocontraction responsesurrogate

Calcium induces vasodilation in pre-contracted rabbit ear vessels through an increase in endothelial nitric oxide synthesis.

Discussion

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Implication

Calcium may induce NO-dependent vasodilation in rabbit vessels; leaves open human relevance and clinical translation.

Cite This Study

Naoyuki Takasugi (1993) studied this question.

synapsesocial.com/papers/6a77fa7bd8eb58afc2be46e1 https://doi.org/10.1254/jjp.61.177

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Calcium-Induced Vasodilation Due to Increase in Nitric Oxide Formation in the Vascular Bed of Rabbit Ear Preparation

Structured PICO

Discussion

Implication

Cite This Study

Calcium-Induced Vasodilation Due to Increase in Nitric Oxide Formation in the Vascular Bed of Rabbit Ear Preparation

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider