Key result
In rabbit hindlimbs, the tachykinin antagonist CP-96,345 and the NO inhibitor L-NAME significantly attenuated nerve stimulation-induced vasodilation (P<0.005 and P<0.001, respectively).
Population
Pentobarbital-anesthetized, paralyzed, and guanethidine-treated rabbits
Comparison
Centrifugal electrical stimulation of the… vs Control resting resistance / baseline responses
Design
Preclinical
Authors
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Tachykinins and NO mediate neurogenic vasodilation in rabbits; leaves open relevance to human vascular regulation.
p-value: p=<0.001
Tachykinins and nitric oxide mediate nerve stimulation-induced vasodilation in rabbit skeletal muscle, suggesting NO is produced subsequent to neural release of tachykinins.
Gustafsson et al. (1994) studied this question. CP-96,345 and L-NAME vs. Control resting resistance was evaluated on Vascular resistance in response to nerve stimulation (p=<0.001). In rabbit hindlimbs, the tachykinin antagonist CP-96,345 and the NO inhibitor L-NAME significantly attenuated nerve stimulation-induced vasodilation (P<0.005 and P<0.001, respectively).
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