Population
Isolated guinea pig pulmonary (PA) and iliac artery (IA) preparations
Comparison
Perivascular nerve stimulation in the presence… vs Intact vs denuded endothelium, and pulmonary vs…
Design
Preclinical
Authors
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Animal data on bed-specific NO sources warrant no clinical extrapolation; leaves open human relevance and mechanisms in pulmonary versus systemic arteries.
The sites of nitric oxide release upon perivascular nerve stimulation differ between vascular beds, involving both endothelium and perivascular nerves in pulmonary arteries but only the endothelium in iliac arteries.
Matsuda et al. (1994) studied this question.
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