Key result
Dogs with dilated cardiomyopathy had a 300% increase in specific activity and a 200% increase in total activity of serum xanthine oxidase compared to healthy controls.
Why the study?
Does serum xanthine oxidase activity serve as a biochemical marker for dilated cardiomyopathy in dogs?
Population
Dogs affected by Dilated cardiomyopathy and healthy dogs serving as control
Comparison
Measurement of serum xanthine oxidase activity vs Healthy dogs serving as control
Design
Preclinical
Authors
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May support xanthine oxidase as a canine dilated cardiomyopathy marker; leaves open its diagnostic utility pending validation studies.
Case-Control
Does serum xanthine oxidase activity serve as a biochemical marker for dilated cardiomyopathy in dogs?
Effect estimate: 300% increase in specific activity
Measurement of xanthine oxidase activity shows significant elevation in dogs with dilated cardiomyopathy, suggesting its potential as an early diagnostic biomarker.
Sesh et al. (2015) conducted a case-control in Dilated cardiomyopathy. Dilated cardiomyopathy vs. Healthy dogs was evaluated on Serum xanthine oxidase activity (300% increase in specific activity). Dogs with dilated cardiomyopathy had a 300% increase in specific activity and a 200% increase in total activity of serum xanthine oxidase compared to healthy controls.
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