Key result
Patients with myocardial infarction had significantly higher blood levels of xanthine oxidase compared to healthy controls (0.0495 vs 0.0102 units/mg protein, p<0.05), demonstrating 100% sensitivity.
Why the study?
Are blood levels of xanthine oxidase and malondialdehyde elevated in patients with acute myocardial infarction compared to healthy controls?
Case-Control (n=150)
Yes
Are blood levels of xanthine oxidase and malondialdehyde elevated in patients with acute myocardial infarction compared to healthy controls?
Absolute Event Rate: 0.0495% vs 0.0102%
p-value: p=<0.05
Xanthine oxidase and malondialdehyde levels are significantly elevated in acute myocardial infarction, suggesting their potential utility as biochemical markers for diagnosis.
Xanthine oxidase elevation was associated with acute MI in case-control data; leaves open prospective validation as a diagnostic biomarker.
Background: the serum markers of myocardial injury are used to help in establishing the diagnosis of myocardial infarction.Objective: to measure the levels of xanthine oxidase activity and malondialdehyde in myocardial infarction patients.Methods: 100 patients with myocardial infarction and 50 healthy persons were included in this study. Xanthine oxidase activity assayed according to the method described by bergmeyer, h.u. while malondialdehyde (MDA) estimation was carried by thiobarbituric acid (TBA) based colorimetric method.Results: significant increasing levels of xanthine oxidase activity and malondialdehyde were found in the blood of the patients with myocardial infarction when compared to healthy persons.Conclusions: we propose the measurement of the blood levels of xanthine oxidase as a marker of myocardial infarction.
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Abdelhamid et al. (2011) conducted a case-control in Myocardial Infarction (n=150). Myocardial infarction vs. Healthy controls was evaluated on Xanthine oxidase level (units/mg protein) (p=<0.05). Patients with myocardial infarction had significantly higher blood levels of xanthine oxidase compared to healthy controls (0.0495 vs 0.0102 units/mg protein, p<0.05), demonstrating 100% sensitivity.
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