What question did this study set out to answer?

To measure the levels and activity of xanthine dehydrogenase and xanthine oxidase in human cardiac tissue.

September 1, 1987AJP Heart and Circulatory Physiology

Free radical-producing enzyme, xanthine oxidase, is undetectable in human hearts

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Authors

LELynne J. EddyAlpha Medical (Slovakia)JSJames R. StewartIndiana University HJH P JonesUniversity of Georgia

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Implication

Biochemical analysis reveals undetectable xanthine oxidase activity in human hearts, suggesting xanthine oxidase inhibitors provide little therapeutic benefit during cardiac ischemia.

Key Points

To measure the levels and activity of xanthine dehydrogenase and xanthine oxidase in human cardiac tissue.
Analyzed myocardial tissue samples obtained from human hearts (N=4).
Evaluated enzyme content using standard spectrophotometric assays alongside sensitive fluorometric assays.
Neither xanthine dehydrogenase nor xanthine oxidase activity was detectable across any of the tested human heart samples.
Human cardiac enzyme activity was determined to be below 2.0 nU/g, indicating xanthine oxidase is not a primary source of oxygen free radicals during human myocardial ischemia.

Cite This Study

Eddy et al. (1987) studied this question.

synapsesocial.com/papers/6a7501e51646b2abe5034a0d https://doi.org/10.1152/ajpheart.1987.253.3.h709

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Implication

Biochemical analysis reveals undetectable xanthine oxidase activity in human hearts, suggesting xanthine oxidase inhibitors provide little therapeutic benefit during cardiac ischemia.

Free radical-producing enzyme, xanthine oxidase, is undetectable in human hearts

Discussion

Member takes

Implication

Key Points

Cite This Study

Free radical-producing enzyme, xanthine oxidase, is undetectable in human hearts

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider