Key result
Treatment with pregnancy termination, insulin, octreotide, and plasmapheresis rapidly decreased triglyceride levels from 9742 mg/dL to 432 mg/dL within 24 hours.
Case Report (n=1)
Plasmapheresis combined with insulin and octreotide rapidly and effectively reduced extreme hypertriglyceridaemia in a pregnant patient with acute pancreatitis.
May support plasmapheresis plus insulin/octreotide for refractory gestational hypertriglyceridemia; hypothesis-generating, controlled trials needed.
Acute pancreatitis due to hypertriglyceridaemia during pregnancy is a rare but severe clinical condition that may cause fatal results for both the mother and the foetus. Acute pancreatitis developed in a 37-year-old pregnant woman with familial hypertriglyceridaemia and diabetes mellitus in the 31(st) week of pregnancy. As intrauterine foetal death developed, the pregnancy of the patient was terminated. Additionally, insulin, octreotide and plasmapheresis with "double membrane filtration" were applied, and triglycerides rapidly decreased. After 24 hours, the level of triglycerides decreased from 9742 mg dL(-1) to 432 mg dL(-1). The patient was discharged from the intensive care unit at the end of 5 days and was discharged from the hospital after 32 days. The current article presents the successful treatment of severe hypertriglyceridaemia in a pregnant case.
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Gök et al. (2015) conducted a case report in Acute pancreatitis due to hypertriglyceridaemia in pregnancy (n=1). Pregnancy termination, insulin, octreotide, and plasmapheresis was evaluated on Triglyceride levels. Treatment with pregnancy termination, insulin, octreotide, and plasmapheresis rapidly decreased triglyceride levels from 9742 mg/dL to 432 mg/dL within 24 hours.
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