Key result
Low molecular weight heparin combined with metformin successfully prevented maternal hypertriglyceridemia-induced pancreatitis and resulted in a full-term delivery in a single pregnant patient.
Why the study?
Hypertriglyceridemia-induced acute pancreatitis in pregnancy is a life-threatening condition that lacks established guidelines for treatment management.
Does low molecular weight heparin combined with metformin prevent hypertriglyceridemia-induced acute pancreatitis in a pregnant woman with severe hypertriglyceridemia?
Case Report (n=1)
No
Does low molecular weight heparin combined with metformin prevent hypertriglyceridemia-induced acute pancreatitis in a pregnant woman with severe hypertriglyceridemia?
Low molecular weight heparin combined with metformin successfully prevented hypertriglyceridemia-induced acute pancreatitis in a high-risk pregnant patient.
May inform individualized HTGP management in pregnancy; leaves open need for prospective trials to guide practice.
Background: Hypertriglyceridemia in pregnancy is a rare but well-known cause of hypertriglyceridemia-induced acute pancreatitis (HTGP) in pregnancy, a life-threatening condition that lacks an established guideline for treatment management. Case presentation: We report a case with a successful treatment management of hypertriglyceridemia in pregnancy. A pregnant woman had been with hypertriglyceridemia for more than seven years and a history of pregnancy termination due to the development of HTGP. Eleven months after her last pregnancy termination, the woman was pregnant again and she started managing her elevated levels of lipids in the second trimester throughout the pregnancy, with low molecular weight heparin and then combined with metformin, to prevent thrombosis. Results: The entire pregnancy progressed smoothly, and the triglycerides' level fluctuated during the second and the third trimester of pregnancy with a range of 16.15 to 47.65 mmol/L. A full-term delivery, with a reasonable outcome for both mother and newborn, was obtained. Compared with her last pregnancy, the outcomes of recent pregnancy were better off. Conclusion: Low molecular weight heparin combined with metformin can avoid maternal hypertriglyceridemia-induced pancreatitis in this single case. To our knowledge, such a combination of treatment management of patients with hypertriglyceridemia in pregnancy to prevent acute pancreatitis has not been reported previously.
No takes yet. Share an insight, caveat, or question.
Peng et al. (2020) conducted a case report in Hypertriglyceridemia in pregnancy (n=1). Low molecular weight heparin combined with metformin vs. Prior pregnancy was evaluated on Prevention of maternal hypertriglyceridemia-induced pancreatitis. Low molecular weight heparin combined with metformin successfully prevented maternal hypertriglyceridemia-induced pancreatitis and resulted in a full-term delivery in a single pregnant patient.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: