Key result
Strict diet plus intermittent IV glucose prevents late-pregnancy pancreatitis in severe familial hypertriglyceridemia.
Why the study?
Women with hypertriglyceridemia are prone to gestational pancreatitis, which carries substantial maternal and fetal risk, and effective management strategies are needed.
Does aggressive dietary therapy combined with intermittent intravenous feeding prevent gestational pancreatitis in a pregnant woman with familial hypertriglyceridemia?
Case Report (n=1)
Does aggressive dietary therapy combined with intermittent intravenous feeding prevent gestational pancreatitis in a pregnant woman with familial hypertriglyceridemia?
Answers are grounded in this paper and cite their sources.
Interrupting oral intake and administering intravenous glucose when triglyceride levels are severely elevated may prevent gestational pancreatitis in women with familial hypertriglyceridemia.
Women with hypertriglyceridemia are prone to gestational pancreatitis, a condition carrying substantial maternal and fetal risk. We describe a 33-year-old woman with familial hypertriglyceridemia who had recurrent hyperlipidemic abdominal crises during previous pregnancies despite dietary fat restrictions. A fifth pregnancy was carried to term without complications after aggressive dietary therapy and intermittent intravenous feeding, administered whenever her triglyceride levels exceeded an arbitrarily selected threshold concentration of 28 mmol/L. The efficacy of this approach may be explained by the published observation that low-fat (high-carbohydrate) isocaloric diets elevate serum triglyceride levels by the oral, but not the intravenous, route in normal individuals. Reduction of this patient's serum triglyceride concentrations by interrupting oral intake and administering intravenous glucose appeared to prevent late-pregnancy pancreatitis and culminated in uncomplicated full-term delivery. (JAMA. 1991;265:1858-1860)
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Sarah G. Sanderson (1991) conducted a case report in Familial hypertriglyceridemia in pregnancy (n=1). Aggressive dietary therapy and intermittent intravenous feeding was evaluated on Prevention of late-pregnancy pancreatitis and full-term delivery. Aggressive dietary therapy and intermittent intravenous glucose prevented late-pregnancy pancreatitis and culminated in uncomplicated full-term delivery in a woman with familial hypertriglyceridemia.
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