Key result
Patients with HFpEF achieved target blood pressure during metaboreflex activation via an exaggerated increase in systemic vascular resistance (+389.5 vs +80 dynes·s-1·cm-5) compared to controls.
Why the study?
Does HFpEF alter the hemodynamic response to metaboreflex activation compared to healthy controls?
Observational (n=22)
Does HFpEF alter the hemodynamic response to metaboreflex activation compared to healthy controls?
Absolute Event Rate: 389.5% vs 80%
HFpEF patients achieve target blood pressure during metaboreflex activation via exaggerated vasoconstriction rather than the normal flow-mediated mechanism seen in healthy controls.
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Suggests distinct BP regulation during metaboreflex in HFpEF; hypothesis-generating and should not yet change practice.
Roberto et al. (2016) conducted an observational in Heart failure with preserved ejection fraction (HFpEF) (n=22). Heart failure with preserved ejection fraction (HFpEF) vs. Age-matched healthy controls was evaluated on Increase in systemic vascular resistance during postexercise muscle ischemia (dynes·s−1·cm−5). Patients with HFpEF achieved target blood pressure during metaboreflex activation via an exaggerated increase in systemic vascular resistance (+389.5 vs +80 dynes·s-1·cm-5) compared to controls.
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