March 25, 2014Catheterization and Cardiovascular Interventions
Percutaneous mitral valve repair with the mitraclip system according to the predicted risk by the logistic EuroSCORE: Preliminary results from the German Transcatheter Mitral Valve Interventions (TRAMI) registry
Key result
In patients undergoing percutaneous mitral valve repair with MitraClip, a logEuroSCORE ≥20 was associated with higher in-hospital mortality compared to a score <20 (4.3% vs 1.1%, P≤0.01).
Why the study?
Does percutaneous mitral valve repair with the MitraClip system have acceptable in-hospital outcomes in high-risk patients (logistic EuroSCORE ≥ 20) compared to lower-risk patients?
Population
1002 patients undergoing percutaneous mitral valve repair with the MitraClip system in the German…
Comparison
Percutaneous mitral valve repair with the… vs Percutaneous mitral valve repair with the…
Design
Cohort
Follow-up
in-hospital
Authors
Discussion
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Member takes
Implication
Supports risk stratification by logEuroSCORE for MitraClip; leaves open net benefit versus medical therapy in highest-risk patients.
Study Design
Type
Observational (n=1,002)
Multicenter
Yes
Structured PICO
Does percutaneous mitral valve repair with the MitraClip system have acceptable in-hospital outcomes in high-risk patients (logistic EuroSCORE ≥ 20) compared to lower-risk patients?
P
Population
1,002 patients who underwent percutaneous mitral valve repair with the MitraClip system, analyzed by logistic EuroSCORE risk.
E
Exposure
Percutaneous mitral valve repair with the MitraClip system in high-risk patients (logistic EuroSCORE ≥ 20).
C
Comparator
Percutaneous mitral valve repair with the MitraClip system in lower-risk patients (logistic EuroSCORE < 20).
O
Outcome
In-hospital mortality, in-hospital MACCE, procedural complications, and residual mitral valve regurgitation.hard clinical
Main Result
Absolute Event Rate: 4.3% vs 1.1%
p-value: p=≤0.01
Percutaneous mitral valve repair with the MitraClip system is feasible in high-risk patients (logEuroSCORE ≥ 20), with in-hospital mortality that is higher than in lower-risk patients but lower than predicted by the surgical risk score.
Cite This Study
Wiebe et al. (2014) conducted an observational in Mitral valve regurgitation (n=1,002). logEuroSCORE ≥ 20 vs. logEuroSCORE < 20 was evaluated on In-hospital mortality (p=≤0.01). In patients undergoing percutaneous mitral valve repair with MitraClip, a logEuroSCORE ≥20 was associated with higher in-hospital mortality compared to a score <20 (4.3% vs 1.1%, P≤0.01).