Key result
MitraClip achieves ~94% device success in hemodynamically unstable patients despite high overall mortality.
Why the study?
Very few data exist on percutaneous mitral valve repair in unstable patients with moderate-severe mitral regurgitation.
Does percutaneous mitral valve repair with MitraClip device improve clinical outcomes and reduce mitral regurgitation in hemodynamically unstable patients with cardiogenic shock or refractory pulmonary edema?
Population
254 critically ill patients with significant MR (Grade 4 in 91%) presenting with cardiogenic shock or acute refractory pulmonary edema
Comparison
Percutaneous mitral valve repair with MitraClip device
Design
Systematic review of 40 publications from 2003 to 2020
Follow-up
12 months
Authors
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May offer rescue option in refractory shock with severe MR; extends feasibility data but high mortality leaves efficacy open pending RCTs.
Systematic Review (n=254)
Does percutaneous mitral valve repair with MitraClip device improve clinical outcomes and reduce mitral regurgitation in hemodynamically unstable patients with cardiogenic shock or refractory pulmonary edema?
Percutaneous mitral valve repair with MitraClip is technically feasible and may be a viable management option for high-risk, hemodynamically unstable patients with moderate-severe mitral regurgitation.
Gómez et al. (2021) conducted a systematic review in Hemodynamically unstable with moderate-severe mitral regurgitation (n=254). Percutaneous mitral valve repair with MitraClip was evaluated on Device success. Percutaneous mitral valve repair with MitraClip in hemodynamically unstable patients achieved device success in 93.7% of cases, with an estimated 12-month overall mortality rate of 39.1%.
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