Key result
Beating-heart implantation of adjustable neochordae using the V-Chordal system eliminated mitral regurgitation in 85.7% of sheep, with stable mitral competence maintained at 3 months.
Why the study?
Does the V-Chordal system improve mitral competence compared to conventional neochordae in an animal model of flail leaflet?
Does the V-Chordal system improve mitral competence compared to conventional neochordae in an animal model of flail leaflet?
Absolute Event Rate: 85.7% vs 50%
The V-Chordal system simplifies neochordal implantation and allows precise off-pump adjustment to effectively correct mitral regurgitation in an animal model.
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Supports further device development for off-pump repair; leaves open human efficacy and safety of the V-Chordal system.
Maisano et al. (2011) studied Mitral regurgitation (flail leaflet model) (n=18). V-Chordal system (adjustable neochordae) vs. Conventional neochordae was evaluated on Absence of mitral regurgitation following repair. Beating-heart implantation of adjustable neochordae using the V-Chordal system eliminated mitral regurgitation in 85.7% of sheep, with stable mitral competence maintained at 3 months.
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