Key result
Short-term (6-month) dual antiplatelet therapy showed no significant difference in the occurrence of late stent thrombosis compared to long-term (12-month) therapy following PCI with second-generation DES (OR 0.98).
Why the study?
To systematically compare the occurrence of late and very late stent thrombosis between a short versus longer duration of DAPT following second-generation DES implantation.
Does short-term DAPT prevent late and very late stent thrombosis compared to long-term DAPT in patients undergoing PCI with second-generation DES?
Meta-Analysis (n=7,142)
Does short-term DAPT prevent late and very late stent thrombosis compared to long-term DAPT in patients undergoing PCI with second-generation DES?
Short-term (3-6 months) DAPT is associated with similar rates of late and very late stent thrombosis compared to long-term (12 months) DAPT following PCI with second-generation DES.
Answers are grounded in this paper and cite their sources.
Supports shorter DAPT after second-generation DES to limit bleeding; confirms similar late stent thrombosis risk versus prolonged regimens.
INTRODUCTION: The aim of this simple meta-analysis was to systematically compare the occurrence of late and very late stent thrombosis with a short versus a longer duration of dual anti-platelet therapy (DAPT) use following the implantation of second-generation drug-eluting stents (DES). METHODS: Randomized controlled trials that compared short- and long-term DAPT use following percutaneous coronary intervention (PCI) with DES and that reported late (> 30 days but < 1 year) and very late (> 1 year) stent thromboses were searched from the bibliographic database of life sciences and biomedical information, which is also known as MEDLINE, as well as other searched databases including EMBASE, the Cochrane Central and http://www.ClinicalTrials.com . Statistical analysis was carried out using RevMan software [odds ratios (OR) and 95% confidence intervals (CIs) represented the results]. The result for very late stent thrombosis was also not significantly different (OR 0.30, 95% CI 0.03-2.95; P = 0.31). CONCLUSIONS: This simple analysis showed no impact of DAPT duration on the occurrence of late and very late stent thrombosis. Similar late and very late stent thrombosis rates were observed with 6-month versus 12-month duration of DAPT use following PCI with second-generation DES.
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Lin et al. (2019) conducted a meta-analysis in Coronary artery disease or acute coronary syndrome (n=7,142). Short-term dual antiplatelet therapy vs. Long-term dual antiplatelet therapy was evaluated on Late stent thrombosis (>30 days but <1 year) (OR 0.98, 95% CI 0.30-3.18, p=0.97). Short-term (6-month) dual antiplatelet therapy showed no significant difference in the occurrence of late stent thrombosis compared to long-term (12-month) therapy following PCI with second-generation DES (OR 0.98).
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