Key result
Atheroma of the aortic arch is an important risk factor for stroke and recurrent stroke, suggesting affected patients likely need more powerful antiplatelet treatment than aspirin alone.
Why the study?
Is combination treatment with aspirin plus clopidogrel more effective than warfarin alone for the secondary prevention of stroke in patients with atheroma of the aortic arch?
Is combination treatment with aspirin plus clopidogrel more effective than warfarin alone for the secondary prevention of stroke in patients with atheroma of the aortic arch?
Atheroma of the aortic arch is an important risk factor for stroke, and optimal antithrombotic management remains uncertain pending the results of ongoing trials like the ARCH study.
Aortic arch atheroma signals need for intensified antithrombotic strategies beyond aspirin; leaves optimal regimen open pending randomized trials.
Atheroma of the aortic arch is an important risk factor for stroke and for recurrent stroke. Optimal management is not known but these patients should probably receive more powerful antiplatelet treatment than aspirin alone. Whether combination treatment with aspirin plus clopidogrel is more effective than warfarin alone is the subject of the ongoing ARCH study.
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Macleod et al. (2003) studied this question. Atheroma of the aortic arch is an important risk factor for stroke and recurrent stroke, suggesting affected patients likely need more powerful antiplatelet treatment than aspirin alone.
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