Key result
Injection of atropine (0.1-0.8 mumoles) into the rat hindlimb perfusion circuit resulted in a dose-dependent decrease in perfusion pressure, suggesting direct vasodilator activity.
Atropine demonstrates direct, dose-dependent vasodilator activity on the peripheral vasculature in a rat model, likely independent of muscarinic mechanisms.
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Hypothesis-generating in rats; leaves open translation of direct atropine vasodilation to human vascular tone or therapy.
The autoperfused hindlimb technique in the rat was used to determine the effects of atropine upon the peripheral vasculature. 2. Injection of atropine (0.1-0.8 mumoles) into the hindlimb perfusion circuit resulted in a dose-dependent decrease in perfusion pressure which was immediate in onset and always preceded systemic pressure changes. The duration of vasodilation lengthened with increasing doses of atropine and ranged from 1.5 to 9 min. 3. During atropine-induced vasodilation, challenging doses of acetylcholine did not alter the perfusion pressure. 4. These experiments suggest that atropine is capable of direct vasodilator activity upon the peripheral vasculature in which a muscarinic mechanism appears unlikely.
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Merrick et al. (1981) studied this question. Atropine was evaluated on Perfusion pressure. Injection of atropine (0.1-0.8 mumoles) into the rat hindlimb perfusion circuit resulted in a dose-dependent decrease in perfusion pressure, suggesting direct vasodilator activity.
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