What question did this study set out to answer?

To evaluate changes in early femoral atherosclerosis over time in hyperlipoproteinemic patients receiving dietary and drug therapy.

February 1, 1977Annals of Internal Medicine

Regression and Progression of Early Femoral Atherosclerosis in Treated Hyperlipoproteinemic Patients

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Authors

RBR. BarndtDrexel University

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Implication

Longitudinal study shows regression of early femoral atherosclerosis in treated hyperlipoproteinemic patients, suggesting early lesions can reverse with lipid and blood pressure control.

Key Points

To evaluate changes in early femoral atherosclerosis over time in hyperlipoproteinemic patients receiving dietary and drug therapy.
Assessed 25 patients (average age 48 years; 12 with type IV and 13 with type II hyperlipoproteinemia; 1 with claudication) treated for elevated lipids and blood pressure with diet and medications.
Conducted baseline and repeat femoral angiograms across a 13-month interval using sensitive radiographic imaging to detect small changes in early lesions.
Follow-up angiograms at 13 months demonstrated lesion regression in 9 patients, stabilization in 3 patients, and progression in 13 patients.
Patients with lesion regression achieved significant reductions in serum cholesterol, triglycerides, and blood pressure, whereas those with lesion progression did not.

Cite This Study

R. Barndt (1977) studied this question.

synapsesocial.com/papers/6a9cf0843a657474307bebcb https://doi.org/10.7326/0003-4819-86-2-139

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Implication

Longitudinal study shows regression of early femoral atherosclerosis in treated hyperlipoproteinemic patients, suggesting early lesions can reverse with lipid and blood pressure control.

Regression and Progression of Early Femoral Atherosclerosis in Treated Hyperlipoproteinemic Patients

Discussion

Member takes

Implication

Key Points

Cite This Study

Regression and Progression of Early Femoral Atherosclerosis in Treated Hyperlipoproteinemic Patients

Discussion

Member takes

Implication

Key Points

Cite This Study

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