Key result
Sequential balloon inflations during coronary angioplasty significantly reduced coronary sinus blood flow (P<0.02) and myocardial oxygen consumption (P<0.05), though the first inflation was unreliable.
Why the study?
Does sequential balloon occlusion during coronary angioplasty provide a reproducible model of myocardial ischaemia in humans?
Population
23 patients undergoing left anterior descending artery angioplasty.
Comparison
Sequential balloon inflations during coronary… vs Baseline measurements before balloon crossing…
Design
Cohort
Authors
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Supports sequential inflations as reproducible ischaemia model after initial dilatation; leaves open first-inflation reliability and generalizability.
Observational (n=23)
Does sequential balloon occlusion during coronary angioplasty provide a reproducible model of myocardial ischaemia in humans?
p-value: p=<0.02
Balloon occlusion during coronary angioplasty can serve as a model of myocardial ischemia in humans, but only subsequent inflations after primary dilatation provide reliable and reproducible ischemic changes.
Perry et al. (1989) conducted an observational in Patients undergoing left anterior descending artery (LAD) angioplasty (n=23). Sequential balloon inflations during coronary angioplasty vs. Baseline measurements before balloon crossing and between inflations was evaluated on Coronary sinus blood flow (CSBF) and myocardial oxygen consumption (MVO2) (p=<0.02). Sequential balloon inflations during coronary angioplasty significantly reduced coronary sinus blood flow (P<0.02) and myocardial oxygen consumption (P<0.05), though the first inflation was unreliable.