Key result
TPA-induced Src activation occurs via direct phosphorylation and activation of PTP alpha by PKC delta, which in turn dephosphorylates and activates Src.
This study identifies a specific molecular pathway in which PKC delta activates Src kinase indirectly through the activation of PTP alpha in smooth muscle cells.
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No immediate clinical implications for vascular disease; leaves open relevance of this pathway in human Src signaling.
Brandt et al. (2003) studied this question. 12-O-tetradecanoylphorbol-13-acetate (TPA) vs. Cells lacking PKC delta was evaluated on Mechanism of PKC-mediated Src activation. TPA-induced Src activation occurs via direct phosphorylation and activation of PTP alpha by PKC delta, which in turn dephosphorylates and activates Src.