Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
April 1, 2004Journal of Biological ChemistryOpen Access

Stimulus-specific Differences in Protein Kinase Cδ Localization and Activation Mechanisms in Cardiomyocytes

View Full Paper
Ask AI
Bookmark
Share

Population

Cardiomyocytes

Comparison

Stimulation with Phorbol 12-myristate 13-acetate… vs Resting cardiomyocytes

Design

Preclinical

Authors

VRVitalyi O. RybinMolecular Cardiology and Neuromuscular InstituteJGJianfen GuoNational Institutes of HealthASAbdelkarim SabriHeart Failure / Cardiomyopathy

Discussion

Loading...

Member takes

Implication

Should not yet inform clinical care; leaves open whether PKCδ mechanisms extend to human cardiac oxidant stress.

Structured PICO

P
Population
Cardiomyocytes
I
Intervention
Stimulation with Phorbol 12-myristate 13-acetate (PMA) or H(2)O(2)
C
Comparator
Resting cardiomyocytes
O
Outcome
PKC delta localization, Tyr(311) phosphorylation, and kinase activitysurrogate

Tyrosine phosphorylation acts as a stimulus-specific mechanism regulating PKC delta localization and substrate specificity in cardiomyocytes during growth factor stimulation and oxidant stress.

Cite This Study

Rybin et al. (2004) studied this question.

synapsesocial.com/papers/6a9ef3402ccf4465eebe33c9https://doi.org/10.1074/jbc.m311096200
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Signaling Pathways in Reactive Oxygen Species–Induced Cardiomyocyte Apoptosis1999 · 573 citations
  2. 2Effect of a tyrosine 155 to phenylalanine mutation of protein kinase Cdelta on the proliferative and tumorigenic properties of NIH 3T3 fibroblasts2000 · 36 citations
  3. 3Dual Actions of the Gα <sub>q</sub> Agonist <i>Pasteurella multocida</i> Toxin to Promote Cardiomyocyte Hypertrophy and Enhance Apoptosis Susceptibility2002 · 72 citations
  4. 4Phosphorylation sites of protein kinase C δ in H <sub>2</sub> O <sub>2</sub> -treated cells and its activation by tyrosine kinase <i>in</i> <i>vitro</i>2001 · 245 citations
  5. 5The therapeutic potential of modulating the ceramide/sphingomyelin pathway2002 · 395 citations