Twelve otherwise healthy male volunteers scheduled for arthroscopy of the knee were studied. The influence in vivo of nitrous oxide (N2O) per se and the addition of a halogenated volatile anaesthetic (halothane or isoflurane) on ADP-induced platelet aggregation and release of beta-thromboglobulin into plasma was evaluated. All measurements were made before surgery. We found that N2O increased platelet aggregation. Adding a halogenated anaesthetic reversed the relative hyperaggregation induced by N2O. The concentrations in plasma of the platelet release product beta thromboglobulin were not influenced by the anaesthetics.
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Nygård et al. (1994) studied this question.
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