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The systemic toxic effects of di-isononyl phthalate (DINP) were evaluated in a 4-wk study in male Sprague-Dawley rats. The animals were administered DINP intravenously at dosages of 125, 250, and 500 mg/kg every other day for 4 wk. The control and the positive control group were administered vehicle (egg yolk phosphatides plus glycerol solutions) and 500 mg/kg di(2-ethylhexyl) phthalate (DEHP), respectively. Clinical signs were observed immediately after administration and consumption of food, and mean body weight was recorded once a week for 4 wk. The absolute and relative organ weights, hematology, clinical chemistry, and pathological changes were evaluated at the end of the study.
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Yanping et al. (2019) studied this question.
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