Key result
Intramedullary nailing for skeletal metastatic disease was associated with a 7.1% overall rate of venous thromboembolism, with lung-cancer histology significantly increasing this risk (p<0.001).
Why the study?
What is the risk of venous thromboembolism in patients undergoing intramedullary nailing for skeletal metastatic disease?
Population
287 patients with 336 impending or pathologic long-bone fractures due to skeletal metastatic disease
Design
Cohort
Authors
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High VTE rates persist despite prophylaxis after metastatic nailing; leaves open optimal regimens for this high-risk population.
Cohort (n=287)
Yes
What is the risk of venous thromboembolism in patients undergoing intramedullary nailing for skeletal metastatic disease?
Patients undergoing intramedullary nailing for skeletal metastatic disease experience a high rate of VTE despite postoperative prophylaxis, suggesting current anticoagulation protocols may be inadequate.
Shallop et al. (2015) conducted a cohort in Skeletal metastatic disease (n=287). Intramedullary nailing was evaluated on Venous thromboembolism (VTE). Intramedullary nailing for skeletal metastatic disease was associated with a 7.1% overall rate of venous thromboembolism, with lung-cancer histology significantly increasing this risk (p<0.001).
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