Key result
Technically successful fetal aortic valvuloplasty acutely improves left heart output in fetuses with mid-gestation aortic stenosis.
Why the study?
Fetal aortic valvuloplasty may avert progression of mid-gestation aortic stenosis to hypoplastic left heart syndrome in a subset of fetuses, but novel assessment of flow through the mitral valve to estimate left heart output after the procedure was needed.
Does fetal aortic valvuloplasty improve left heart output in fetuses with mid-gestation aortic stenosis?
Does fetal aortic valvuloplasty improve left heart output in fetuses with mid-gestation aortic stenosis?
Fetal aortic valvuloplasty acutely improves left heart output in fetuses with aortic stenosis, as assessed by a novel measurement of mitral valve flow.
Answers are grounded in this paper and cite their sources.
Does not support routine fetal aortic valvuloplasty; hypothesis-generating for long-term outcomes in congenital aortic stenosis.
Key points What is known? Fetal aortic valvuloplasty (FAV) may avert the progression of mid‐gestation aortic stenosis (AS) to Hypoplastic left heart syndrome (HLHS) in a subset of fetus. What this study adds? Novel assessment of flow through the mitral valve (MV) to estimate left heart output in fetus with AS after a FAV.
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Asrani et al. (2022) studied this question. Technically successful fetal aortic valvuloplasty acutely improves left heart output in fetuses with mid-gestation aortic stenosis.
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