Key result
Endogenous angiotensin II released from endothelial cells decreases interleukin-1beta-stimulated inducible nitric oxide synthase expression in the vascular wall via an AT-1 receptor-dependent mechanism.
Endogenous angiotensin II released from endothelial cells inhibits interleukin-1beta-stimulated inducible nitric oxide synthase expression via AT-1 receptors in rat aortic vessels.
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No immediate clinical implications in hypertension; leaves open translation of endothelial AT1-iNOS effects to humans.
Montón et al. (1997) studied this question. Angiotensin II vs. Deendothelialized aortic segments was evaluated on Inducible nitric oxide synthase expression and nitrite release. Endogenous angiotensin II released from endothelial cells decreases interleukin-1beta-stimulated inducible nitric oxide synthase expression in the vascular wall via an AT-1 receptor-dependent mechanism.
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