Key result
Thrombin and poly-l-lysine impaired the incorporation of acetate and glycerol into complex lipids in washed human platelets, suggesting that primary platelet aggregation is associated with a defect in complex lipid assembly.
Population
Washed human platelets (0.6-1.5 x 10^9 platelets/ml) prepared from normal subjects
Comparison
Platelet aggregation induced by thrombin or… vs Non-aggregated control platelets
Design
Preclinical
Follow-up
60 minutes (incubation time)
Authors
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Implicates lipid defects in primary aggregation; leaves open relevance to in vivo thrombosis or antiplatelet strategies.
Effect estimate: 65% reduction
Absolute Event Rate: 133% vs 480%
p-value: p=<0.001
Primary platelet aggregation induced by thrombin or poly-l-lysine is associated with a defect in the assembly of complex lipids.
Daniel Deykin (1973) studied Normal human platelets. Thrombin and poly-l-lysine vs. Control platelets (buffer/plasma without aggregating agents) was evaluated on Acetate incorporation into total platelet lipids (65% reduction, p=<0.001). Thrombin and poly-l-lysine impaired the incorporation of acetate and glycerol into complex lipids in washed human platelets, suggesting that primary platelet aggregation is associated with a defect in complex lipid assembly.
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