Key result
Peripartum cardiomyopathy occurred in 1 of 8,135 deliveries, with 1 of 5 diagnosed cases presenting with stroke due to a left ventricular mural thrombus identified by cardiac imaging.
Case Report (n=5)
No
Peripartum cardiomyopathy is a rare condition that can present with stroke due to left ventricular mural thrombus, which can be diagnosed with advanced cardiac imaging.
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Cardiac imaging may detect treatable LV thrombus in peripartum stroke; case-level data leaves open need for prospective studies.
In the United States, peripartum cardiomyopathy (PC) is an uncommon form of dilated cardiomyopathy, which, when associated with stroke, results in a high mortality rate. The estimated incidence of PC at the University of Iowa Hospitals and Clinics from 1/1/1976 to 7/1/1993 averaged only 1 out of every 8,135 deliveries. Of the total 5 cases diagnosed, only 1 presented with neurologic manifestations. Through the use of echocardiography, cine-computerized tomography and magnetic resonance imaging, a large left ventricular mural thrombus in a diffusely hypokinetic heart was found. Newer cardiac imaging techniques are improving our ability to diagnose the cause of stroke in the younger population, including women in the peripartum period, allowing early institution of appropriate medical treatment and hopefully improving prognosis.
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Dyken et al. (1994) conducted a case report in Peripartum cardiomyopathy and stroke (n=5). Peripartum cardiomyopathy was evaluated on Neurologic manifestations. Peripartum cardiomyopathy occurred in 1 of 8,135 deliveries, with 1 of 5 diagnosed cases presenting with stroke due to a left ventricular mural thrombus identified by cardiac imaging.
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