August 1, 1992Critical Care Medicine
Addition of enoximone to adrenergic agents in the management of severe heart failure
Key result
Direct intravenous injections of enoximone (0.125 mg/kg) significantly increased mean cardiac index from 1.58 to 1.84 L/min/m2 (p<0.01) in patients with severe heart failure.
Why the study?
Does the addition of small IV bolus doses of enoximone to adrenergic therapy improve hemodynamic parameters in patients with severe heart failure?
Population
22 patients with severe heart failure and signs of altered tissue perfusion associated with a low cardiac…
Design
Cohort, Open label
Authors
Discussion
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Implication
Enoximone boluses were associated with higher cardiac index in severe HF; hypothesis-generating for adjunctive use and requires randomized confirmation.
Structured PICO
Does the addition of small IV bolus doses of enoximone to adrenergic therapy improve hemodynamic parameters in patients with severe heart failure?
P
Population
22 critically ill patients (12 post-cardiac surgery, 10 with cardiomyopathy) with severe heart failure and low cardiac index despite adrenergic therapy.
I
Intervention
Small IV bolus doses of enoximone (0.25 mg/kg or 0.125 mg/kg) added to adrenergic therapy.
O
Outcome
Hemodynamic effects including cardiac index, left ventricular stroke work index, heart rate, and mean arterial pressure.surrogate
Main Result
Absolute Event Rate: 1.84% vs 1.58%
p-value: p=<.01
Small IV bolus doses of enoximone safely improve cardiac index without compromising arterial pressure in critically ill patients with severe heart failure refractory to adrenergic therapy.
Cite This Study
Vincent et al. (1992) studied severe heart failure (n=22). enoximone was evaluated on cardiac index (p=<.01). Direct intravenous injections of enoximone (0.125 mg/kg) significantly increased mean cardiac index from 1.58 to 1.84 L/min/m2 (p<0.01) in patients with severe heart failure.