Key result
Electrical stimulation of the dorsal medulla in cats identified lateral and medial inhibitory areas and an intermediate facilitatory area mediating ACTH release (P<0.01).
Population
11 cats anesthetized with chloralose/urethane
Design
Preclinical
Authors
Loading...
Does not inform clinical HPA management; hypothesis-generating for medullary ACTH control in translational models.
p-value: p=<0.01
The study maps specific inhibitory and facilitatory areas in the dorsal medulla of cats that mediate ACTH release, likely in response to hemodynamic changes such as atrial stretch.
Ward et al. (1976) studied this question. Electrical stimulation of the dorsal medulla was evaluated on Release of ACTH (delta ACTH pg/ml) (p=<0.01). Electrical stimulation of the dorsal medulla in cats identified lateral and medial inhibitory areas and an intermediate facilitatory area mediating ACTH release (P<0.01).
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: