Synthesis of (-)-Idiadione, a Furanosesterterpene Isolated from a Marine Sponge Spongia idia

Idiadione (1) , a furanosesterterpene isolated from a marine sponge Spongia idia, was synthesized, starting from (S)-(-)-citronellal (2) .The absolute configuration of naturally occurring 1 is established as (S) .The linear furanosesterterpene idiadione (1) was first isolated in 1980 by Faulkner et al.1 from a marine sponge Spongia idia (Leiosella idia).Faulkner reported that idiadione (1) is toxic to the sea star, brine shrimp and ectoproct.1 has also antifeedant activity 2 against fish.