January 1, 2003Pacing and Clinical Electrophysiology
Ventricular Dyssynchrony and Risk Markers of Ventricular Arrhythmias in Nonischemic Dilated Cardiomyopathy:
Key result
Left intraventricular dyssynchrony evaluated with ERNA was an independent predictor of major adverse cardiac events (P=0.003) in patients with idiopathic dilated cardiomyopathy.
Why the study?
Does ventricular dyssynchrony evaluated with ERNA predict major adverse cardiac events in patients with idiopathic dilated cardiomyopathy?
Study Design
Type
Cohort (n=103)
Structured PICO
Does ventricular dyssynchrony evaluated with ERNA predict major adverse cardiac events in patients with idiopathic dilated cardiomyopathy?
P
Population
103 patients with idiopathic dilated cardiomyopathy followed for a mean of 27 months.
E
Exposure
Evaluation of ventricular dyssynchrony (inter- and intraventricular) using Fourier phase analysis from equilibrium radionuclide angiography (ERNA)
O
Outcome
Major adverse cardiac events (MACE), including cardiac death, progression of heart failure leading to cardiac transplantation, and sustained VT/VFcomposite
Main Result
p-value: p=0.003
Left intraventricular dyssynchrony evaluated with ERNA is an independent predictor of MACE in idiopathic dilated cardiomyopathy, independent of usual ventricular arrhythmia risk markers.
Authors
Discussion
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Implication
May refine MACE risk stratification in idiopathic dilated cardiomyopathy; hypothesis-generating and requires prospective validation before clinical use.
Cite This Study
Fauchier et al. (2003) conducted a cohort in Idiopathic dilated cardiomyopathy (IDC) (n=103). Left intraventricular dyssynchrony vs. Lower intraventricular dyssynchrony was evaluated on Major adverse cardiac events (MACE) (p=0.003). Left intraventricular dyssynchrony evaluated with ERNA was an independent predictor of major adverse cardiac events (P=0.003) in patients with idiopathic dilated cardiomyopathy.