Key result
Anoxia induced lactic acid accumulation and intracellular proteolysis in both infant and adult rat hearts, with cathepsin activity being almost twice as high in adult hearts at pH < 5.
Authors
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May inform age-specific myocardial responses to anoxia; leaves open clinical translation in human ischemia.
DeHaan et al. (1959) studied Anoxia. Anoxia vs. Adult vs infant rat heart muscle was evaluated on Lactic acid production, buffer capacity, and proteolytic activity. Anoxia induced lactic acid accumulation and intracellular proteolysis in both infant and adult rat hearts, with cathepsin activity being almost twice as high in adult hearts at pH < 5.
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