What question did this study set out to answer?

Evaluate the broad antiparasitic efficacy, mechanisms of action, and pharmacological properties of compounds within the open-access Malaria Box across distributed global research screens.

July 28, 2016PLoS PathogensOpen Access

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

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Evaluate the broad antiparasitic efficacy, mechanisms of action, and pharmacological properties of compounds within the open-access Malaria Box across distributed global research screens.
Analyzed screening data from 236 novel biological assays and 55 previously published screens conducted on the 400-compound Malaria Box distributed to nearly 200 global research groups.
Assayed compounds across multiple Plasmodium falciparum developmental stages, non-malaria organisms (16 protozoa, 7 helminths, 9 bacterial species), dengue mosquito vectors, and the NCI60 tumor cell line panel.
Profiled toxicological, pharmacokinetic, and metabolic properties for all library molecules to identify candidate leads for in vivo testing.
Identified mechanisms of action for 135 compounds (34%) exhibiting activity across asexual blood, liver, gametocyte, and insect ookinete stages of Plasmodium falciparum.
Demonstrated broad-spectrum activity beyond malaria, showing cross-pathogen hits across 16 protozoan species, 7 helminths, 9 bacterial/mycobacterial species, and NCI60 human cancer cell lines.

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Implication

Meta-analysis reveals broad antimicrobial and antiparasitic efficacy across multiple pathogen models, highlighting the power of open-source compound sharing for accelerated drug discovery.

Cite This Study

Voorhis et al. (2016) studied this question.

synapsesocial.com/papers/6a9d6d04a99ff5a58a67f850 https://doi.org/10.1371/journal.ppat.1005763

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Implication

Meta-analysis reveals broad antimicrobial and antiparasitic efficacy across multiple pathogen models, highlighting the power of open-source compound sharing for accelerated drug discovery.

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

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Discussion

Implication

Cite This Study

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

Key Points

Discussion

Implication

Cite This Study

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